Definitions
1.NounAn abnormal condition of a human, animal or plant that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired."The tomato plants had some kind of disease that left their leaves splotchy and their fruit withered.; The exposed workers had some kind of disease that left their skin splotchy and their faces withered."
2.NounAny abnormal or harmful condition, as of society, people's attitudes, way of living etc.
3.NounA lack of ease; uneasiness; trouble; vexation; disquiet.
4.VerbTo cause unease; to annoy, irritate.
5.VerbTo infect with a disease.