Definitions
1.verbTo move, arrange or operate something using the hands
2.verbTo influence, manage, direct, control or tamper with something
3.verbTo handle and move a body part, either as an examination or for a therapeutic purpose
4.verbTo influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
5.verbTo use the hands, especially in scientific experiments.