1.VerbTo succeed in doing something, for example in reaching a place, going somewhere, attending an event, arriving in time for something, adding to one's schedule or itinerary, or in getting where one wants to be in one's life or career, which sometimes means becoming or wanting to become successful (succeed in a big way) or famous.
"He never made it to Italy despite talking about it all his life.; I can't make it to the concert; I have to work.; I'm not just going to make it; I'm going to make it big.; As long as we have each other, it doesn't make a difference if we make it or not."
2.VerbTo succeed in surviving, in living through something.
3.VerbTo have sexual intercourse.
4.VerbUsed other than figuratively or idiomatically: see make, it.
"The blisters on my foot made it a problem to walk without a cane."