"This computer is buggered! Oh no! I've buggered it up."
3.verbTo be surprised.
"Bugger me sideways!"
4.verbTo feel contempt for some person or thing.
"Bugger Bognor. (Alleged to be the last words of King George V of the United Kingdom in response to a suggestion that he might recover from his illness and visit Bognor Regis.)"
5.verbTo feel frustration with something, or to consider that something is futile.